Investigation of the Therapeutic Effects of Chloroquine in Adriamycin-Induced Hepatotoxicity

Abstract The aim of this study is to investigate the therapeutic effects Chloroquine (CLQ) against Adriamycin (ADR) induced hepatotoxicity. ADR a chemotherapeutic agent used in treatment many cancer types, but it causes CLQ as an anti-inflammatory drug malaria, rheumatoid arthritis, and pneumonia caused by Covid-19. Rats were divided into four groups: Control group, group (2 mg/kg Adriamycin, one three days for 30 days, i.p.), (50 Chloroquine, per day ADR+CLQ i.p. 50 mg/ kg i.p.). Animals sacrificed, liver tissues extracted further examinations. Histopathological changes scored IL-17 immunostaining was performed determine expression levels among experimental groups. Bodyweights decreased significantly compared group. Furthermore, bodyweight higher histopathological score when while administrations reduced damage immunoreactivity considerably increased On other hand, expressions substantially less We suggest that can be reduce detrimental ADR, thanks its properties.